Change in Overhauser Effect-enhanced MRI Signal in Response to uPA Highly Expressing in Tumor

Niidome T; Chijiiwa N; Yamasaki T; Yamada K; Mori T; Naganuma T; Utsumi H; Ichikawa K; Katayama Y

Chemistry Letters, Vol.43, No.7, 999-1001, 2014

Niidome T, Chijiiwa N, Yamasaki T, Yamada K, Mori T, Naganuma T, Utsumi H, Ichikawa K, Katayama Y

Dendritic poly(L-lysine) polymers were modified with stable nitroxyl radicals through the substrate peptides of a protease specifically expressed in tumors. Cleavage of the peptides by the protease affected the Overhauser-enhanced MRI (OMRI) signal from the radicals. This system could be the basis of a functional tumor-imaging technique by OMRI.