The synthesis of chiral compounds through dynamic kinetic resolution has shown improved results with the presence of racemization. Integrating the reaction media for biocatalytic kinetic resolution and base-catalyzed racemization pose challenges in chiral separation due to its alkaline environment. Base-catalyzed racemization of (R)-ibuprofen ester has been separately studied in isooctane, isooctane water, and isooctane DMSO media. A rapid racemization rate of (R)-ibuprofen ester was obtained in isooctane-DMSO medium as compared with the other two media with racemization rate constants (k(rac)) of 0.292 and 0.001 h(-1), respectively. An investigation carried out on sodium hydroxide and Amberlyst A26 (OH- resin) as base catalysts has shown that Amberlyst A26 gave a better performance compared to that of sodium hydroxide. Additionally, the rate of racemization increases at higher reaction temperatures, but shows otherwise at a higher concentration of substrate. The kinetic model of the base-catalyzed racemization was developed and experimentally validated. The model incorporates two main contributing factor's in the racemization reaction: a base catalyst and initial substrate concentrations. Base-catalyzed racemization was conducted in the proposed packed-bed reactor, where the racemization rate was faster with an increased velocity of feed flow rate. The absolute rate constants of racemization (k(abs)) obtained were 0.112 and 0.275 h(-1) for feed flow rates of 0.6 and 1.2 mL. min(-1), respectively. The packed-bed reactor was then proposed to be coupled with a membrane reactor as an integrated dynamic kinetic resolution reactor of chiral compounds.