The aim of present study was to measure and correlate the mole fraction solubility of olmesartan medoxomil (OLM) in six green solvents, namely, water, ethanol, propylene glycol (PG), polyethylene glycol-400 (PEG-400), ethylene glycol (EG), and Transcutol from (295.15 to 330.15) K at atmospheric pressure using the shake flask method. The experimental solubilities of OLM were correlated with the Apelblat equation. The root-mean-square deviations between experimental and calculated solubility were observed in the range of 3.360 X 10(-8) to 0.013 X 10(-3) in all green solvents. However, the correlation coefficients in water, ethanol, PG, PEG-400, EG, and Transcutol were observed in the range of 0.996-0.998, indicating a good fit. The solubility of OLM was found to be higher in PEG-400 (2.58 X 10(-3) at 298.15 K) and Transcutol (2.48 X 10(-3) at 298.15 K) as compared to water (2.32 X 10(-7) at 298.15 K), ethanol (4.67 X 10(-4) at 298.15 K), PG (9.23 X 10(-5) at 298.15 K) and EG (6.73 X 10(-5) at 298.15 K).