Corrosion is among the principal causes of damage and failure in pipeline systems and is linked to various economic and environmental risks. The consideration of corrosion phenomena at the early stages of pipeline system design can help quantify these risks and include risk reduction alternatives in the analysis. The present work builds upon previous research on the optimization of pipeline systems and to consider corrosion factors in making preliminary decisions on routing and equipment selection. The optimization tool is herein extended by including corrosion models and upgrading the equipment design and cost functions. The proposed developments are tested against a case study involving a crude oil pipeline system and a range of corrosion related properties for the transmitted fluid.