For a multi-input multi-output nonlinear system, an optimal integral sliding mode control scheme based on pseudospectral method is proposed in this paper. And the controller is applied on rigid robotic manipulators with constraints. First, a general form of integral sliding mode is designed with the aim of restraining disturbance. Then, pseudospectral method is adopted to deal with constrained optimal control problem. In consideration of the benefits of both methods, an optimal integral sliding mode controller is given, which is based on the combination of integral sliding mode and pseudospectral method. The stability analysis shows that the controller can guarantee stability of robotic manipulator system. Simulations show the effectiveness of proposed method.