In previous proof-of-concept studies, feasibility of a new airlift-raceway configuration and its energetic advantage and improved CO2 utilization efficiency over the traditional raceways and photobioreactors have been documented. In the current study, a mathematical model for predicting biomass growth in the airlift-raceway reactor is presented, which includes supply and transfer of CO2 and the synergetic effects of light, CO2, nitrogen, and temperature. The model was calibrated and validated with data from prototype scale versions of the reactor on two test species: Nannochloropsis saline and Scenedesmus sp., cultivated under indoor and outdoor conditions. Predictions of biomass concentrations by the proposed model agreed well with the temporal trend of the experimental data, with r(2) ranging from 0.96 to 0.98, p < 0.001. A sensitivity analysis of the 10 model parameters used in this study revealed that only three of them were significant, with sensitivity coefficients ranging from 0.08 to 0.13. (C) 2013 Elsevier Ltd. All rights reserved.