This article reports on a microreactor/microwave high-pressure flow hybrid apparatus of a novel concept design, which includes both the microreactor and a spiral reactor, and its efficient use in the synthesis of silver nanoparticles of relatively uniform sizes (4.3 +/- 0.7 nm) under microwave irradiation. By contrast, under otherwise identical experimental conditions but with conventional heating, the nanoparticle size was non-uniform (8.3 +/- 2.7 nm) and the spiral reactor walls were covered with a silver mirror deposit. Formation of the nanoparticles was monitored by UV-visible spectroscopy (plasmonic absorption band; LSPR), TEM and by small-angle X-ray scattering (SAXS). Both the spiral microreactor and the spiral quartz reactor of the hybrid system played an important role in the synthesis, with the microreactor providing the environment wherein mixing of the aqueous solution of [Ag(NH3)(2)](+) and the solution of glucose (the reducing agent) and poly(N-vinyl-2-pyrrolidone) (PVP; stabilizer/dispersing agent) occurred. The microwaves provided the thermal energy to effect a uniform growth of the silver nanoparticles at temperatures above 120 C. Mixing the two solutions by conventional methods (no microreactor) failed to yield such nanoparticles even under microwave irradiation and no formation of a silver mirror occurred in the inner walls of the spiral reactor. (c) 2013 Elsevier BY. All rights reserved.