A whole series of significant catalytic processes are carried out in a slurry reactor with multiple impellers. The selective hydrogenation of sunflower seed oil is the characteristic example of such a process. The liquid phase is the main medium into stirred tank and an investigation of a fluid dynamics of one just as transient regime of solid distribution in liquid volume could be helpful to practical application. In the present work, CFD simulations have been carried out to study solid distribution in liquid-solid stirred tank using Mixture multifluid approach along with standard k-epsilon turbulence model. A multiple frame of reference (MFR) and Sliding Mesh Model have been used to model the multiple impellers and tank region. The effects of specific density of fine-dispersed solid phase and place of injection of solid have been investigated for "steady-state" and time-depended cases. (C) 2011 Elsevier B.V. All rights reserved.