In this paper, a new analytical method named DTM-BF is proposed and applied to study the MHD mixed convective flow and heat transfer of an incompressible, viscous and electrically conducting fluid over a stretching permeable wedge in the presence of thermal radiation and ohmic heating. The boundary layer governing equations of PDES are transformed into highly nonlinear coupled ODES and the approximate solutions are derived by the new proposed analytical technique the differential transformation and basis functions method (DTM-BF) on unbounded domains. The effects of the velocity ratio parameter, magnetic field parameter, the wedge angle parameter, the mixed convection parameter, suction/injection parameter, thermal radiation parameter, Eckert number and Prandtl number are presented. Moreover, the reliability and effectiveness of the DTM-BF have been verified by comparing analytical results with numerical solutions. Some new characteristics of the mixed convective flow and heat transfer over a wedge are investigated and discussed. (C) 2012 Elsevier Ltd. All rights reserved.