Hydrocarbon processes are frequently accompanied by catalyst deactivation through coke deposition on the catalyst surface. A control strategy is proposed for catalyst regeneration in a novel dehydrogenation process designed to be operated in a cyclic production-regeneration mode. The task of the controller is to ensure complete regeneration while maintaining strict limits regarding regeneration time and maximum temperature. The major challenge arises from the uncertainty in the total amount and the spatial distribution of coke loading. The problem is tackled by a model-based approach. This includes a modular analysis of the open-loop behavior and a consistent controller configuration. (C) 2011 Elsevier Ltd. All rights reserved.