Improved dispersion of fine (<30 mu m) and ultrafine powders (<100 nm) in gas medium is addressed. For fine powders, two surface modification approaches for producing dispersible powders are considered: first, suitable for powders >10 mu m where attrition is minimum, and second, suitable for finer particles including inhalable (25 mu m), where simultaneous micronization and surface modification is performed. In addition to improved dispersibility, surface modification is found to add significant corresponding benefits such as improved flowability, aeratibility or fluidizability and packing densities, leading to potential cost savings in handling and storage. Dispersibility of surface modified fine powders is assessed using Sympatec/Rodos through dispersion pressure titration. Flowability and bulk density improvements as corroborative measures are assessed using Hosokawa Powder Tester and FT4 Freeman Powder Rheometer. The indices such as flow function coefficient, angle of repose, bulk density and aeration are measured. For ultrafine powders (nano-particles <100 nm), where surface modification is not applicable, deagglomeration via rapid expansion of high pressure or supercritical suspensions (REHPS) of nano-particle aggregates is considered and shown to be highly effective for their dispersion. The size distribution of fragmented nano-powders is characterized by online Scanning Mobility Particle Spectrometer (SMPS) and by offline Scanning Electron Microscopy (SEM). SMPS and SEM measurements indicate that the average agglomerate sizes are well below 1 mu m, consistent with the length scales observed in our complementary REHPS mixing experiments using alumina and silica nano-powders. In summary, industrially relevant powder dispersion approaches are presented, applicable to both fine and ultrafine powders. (C) 2012 Elsevier B. V. All rights reserved.