An experimental demonstration of the interference between two different resonant two-photon, two-color ionization processes from the A (2) Sigma(+), upsilon’=1 State of nitric oxide is presented. This interference effect does not require a well-defined phase relationship between the two ionizing lasers and should, in principle, allow the control of the overall ionization process by small detunings of either or both of the two resonant ionization pathways. This interference effect is quite general, and the potential of this scheme for the control of photoionization and photodissociation partial cross sections is discussed.