The combination of Forward Osmosis (FO) and Reverse Osmosis (RO) was evaluated for seawater desalination. RO process was suggested for the draw solution regeneration because of its high efficiency and applicability for a wide range of ionic solution treatments. Two different salts, NaCl and MgCl2, were used as a draw solution. The performance of FO and RO regeneration processes was simulated using pre-developed software. A comparison between the RO and FO-RO processes was carried out. The simulation results showed that the total power consumption in the RO was lower than that in the FO-RO process. But, the difference in total power consumption between the RO and 0.65 mol MgCl2 FO-RO processes was insignificant. The results also showed that the power consumption in the FO process was only 2%-4% of the total power consumption in the FO-RO process. However, the difference in total power consumption between the RO process and the FO-RO process decreased with a higher seawater salinity. In the FO-RO process, the results showed that the permeate TDS was increased with increasing the concentration of draw solution. The lowest permeate TDS was achieved in the 0.65 mol MgCl2 FO-RO process and it was attributed to the high rejection rate of MgCl2 by the RO regeneration unit. (C) 2014 Elsevier B.V. All rights reserved.