This study aimed to develop an electrode chemically modified with cucurbit[6]uril to detect 3,4-methylenedioxymethamphetamine (MDMA), the main active principle of ecstasy samples, by voltammetry. We modified the electrode surface with a film containing cucurbit[6]uril, Nafion, and methanol, using the dip coating or the spin coating technique. During analysis, we employed an electrochemical cell with a conventional three-electrode system and KCl solution (0.1 mol L-1) as the supporting electrolyte. We conducted cyclic voltammetry at concentrations ranging from 4.2 x 10(-6) to 4.8 x 10(-5)mol L-1. We also accomplished scanning electron microscopy, to investigate the structural behavior of the film that originated on the electrode surface. We obtained the following results when we used dip coating to prepare the modified electrode: standard deviation (SD) = 0.024 mu A, limit of detection (LOD) = 3.5 mu mol L-1, limit of quantification (LOQ) = 11.7 mu mol L-1, and amperometric sensitivity (m) = 20.9 x 10(3) mu A L mol(-1). As for spin coating, we obtained SD = 0.024 mu A, LOD =2.7 mu mol L-1, LOQ = 9.1 mu mol L-1 and m = 25.9 x 10(3) mu A mol L-1. These are very promising data: the modified electrode is more sensitive than the conventional glassy carbon electrode under the studied experimental conditions. (C) 2014 Elsevier Ltd. All rights reserved.