Control strategies for auto-ignition control in turbocharged internal combustion engines operating with gaseous fuels are presented. Ambient temperature and ambient pressure are considered as the disturbing variables. A thermodynamic model for predicting temperature at the ignition point is developed, adjusted and validated with a large experimental data-set from high power turbocharged engines. Based on this model, the performance of feedback and feedforward auto-ignition control strategies is explored. A robustness and fragility analysis for the Feedback control strategies is presented. The feedforward control strategy showed the best performance however its implementation entails adding a sensor and new control logic. The proposed control strategies and the proposed thermodynamic model are useful tools for increasing the range of application of gaseous fuels with low methane number while ensuring a safe running in internal combustion engines. (C) 2014 Elsevier Ltd. All rights reserved.