This study measured an actual behavior of a multi-story double skin facade (DSF) in South Korea. The verification of simulation model was made against measured data, and a case study was conducted based on the verified model. Seasonal load characteristics of the DSF building were examined in comparison with the single skin facade (SSF) building, and seasonal operation strategies of the DSF were proposed. The DSF building resulted in 15.8% and 7.2% reductions in heating and cooling energy consumption respectively, compared to the SSF building. In the proposed model of heating seasons, heated air in the cavity was introduced to an outdoor air (OA) mixing box of a HVAC system. In the proposed model of cooling seasons, air in the cavity was flowed into an indoor space through inner layer openings for natural ventilation, and outdoor air supply in a AHU was controlled based on the amount of the natural ventilation. These seasonal proposed models resulted in 28.2% and 2.3% reductions in heating and cooling energy consumption respectively, compared to the DSF model to which operation strategies were not applied. (C) 2013 Elsevier B.V. All rights reserved.