A milk pasteurization process, a nonlinear process and multivariable interacting system, is difficult to control by the conventional on-off controllers since the on-off controller can handled the temperature profiles for milk and water oscillating over the plant requirements. The multi-variable control approach with model predictive control (MPC) is proposed in this study. The proposed algorithm was tested for control of a milk pasteurization process in four cases of simulation such as set point tracking, model mismatch, difference control and prediction horizons, and time sample. The results for the proposed algorithm show the well performance in keeping both the milk and water temperatures at the desired set points without any oscillation and overshoot and giving less drastic control action compared to the cascade generic model control (GMC) strategy. (C) 2014 Elsevier Ltd. All rights reserved.