Radiant panels are known to be energy efficient sensible heating and cooling systems and a suitable fit for low-exergy buildings. This paper points out the little known fact that this may not necessarily be true unless their low-exergy demand is matched with low-exergy waste and alternative energy resources. In order to further investigate and metricate this condition and shed more light on this issue for different types of energy resources and energy conversion systems coupled to radiant panels, a new engineering metric was developed. Using this metric, which is based on the Rational Exergy Management Model, true potential and benefits of radiant panels coupled to ground-source heat pumps were analyzed. Results provide a new perspective in identifying the actual benefits of heat pump technology in curbing CO2 emissions and also refer to IEA Annex 49 findings for low-exergy buildings. Case studies regarding different scenarios are compared with a base case, which comprises a radiant panel system connected to a natural gas-fired condensing boiler in heating and a grid power-driven chiller in cooling. Results show that there is a substantial CO2 emission reduction potential if radiant panels are optimally operated with ground-source heat pumps driven by renewable energy sources, or optimally matched with combined heat and power systems, preferably running on alternative fuels. (C) 2012 Elsevier Ltd. All rights reserved.