The solubility of puerarin in methanol and acetic acid solvent mixtures was measured by a static analytical method at temperatures ranging from (293.15 to 333.15) K. The mass fraction of acetic acid in the solvent mixtures (w(3)) ranges from 0 to 0.6. The Apelblat equation was applied for correlating the experimental solubility data, and subsequently used to derive the apparent molar enthalpy, Gibbs energy, and entropy of dissolution of puerarin in methanol + acetic acid binary mixtures. (C) 2012 Elsevier B.V. All rights reserved.