In this work the vapor-liquid equilibrium for the {CO2(1) + dichloromethane(2) + medroxyprogesterone (3)} system were measured for different concentrations of medroxyprogesterone in dichloromethane (0.01 g mL(-1) and 0.02 g mL(-1)) at temperatures ranging from (303 to 333)K and pressure up to 8.6 MPa. The experimental data were obtained using a visual synthetic static method employing a variable volume cell. The liquid-vapor transitions were classified as a bubble points and dew points in the presence or absence of solid phase. The experimental vapor-liquid equilibrium data were satisfactory correlated using the Peng-Robinson equation of state with a quadratic mixing rule. (C) 2013 Elsevier B.V. All rights reserved.