Biodiesel is a fuel composed by fatty acid esters, usually methyl esters (FAME), have common structural features, as allylic hydrogens, bis-allylic hydrogens and secondary hydroxyl, that determinate its oxidative stability. In this study, the oxidation temperature (OT) of biodiesels formulated from a mixture design of methyl stearate, methyl oleate, methyl linoleate and methyl ricinoleate was determined by pressurized differential scanning calorimetry (PDSC). The generic representation CaHbHc*H-d**H-e***O-2(OH)(f) for the mixtures was developed and their coefficients were used as parameters to describe the OT. A non-linear dependence of OT with the descriptors of allylic hydrogen H-c*, bis-allylic hydrogen H-d* and secondary hydroxyls (OH)(f) were observed in the empirical domain D-exp = {(a;c,d,f) is an element of R-3; 0 <= c <= 4 and 0 <= d <= 2 and 0 <= f <= 1 and a = 19}, where the C-a parameter for chain length was kept fixed. (C) 2012 Elsevier Ltd. All rights reserved.