The purpose of the present study is to clarify the influence of CO2 hydrate formation on liquid CO2 flow injected into a packed bed which simulate seabed. In order to reveal the influence of CO2 hydrate on liquid CO2 flow, differential pressure and temperature are measured under the conditions with CO2 hydrate formation and without CO2 hydrate formation. As the result, for liquid CO2 flow with the hydrate formation, differential pressure at the upstream part of the packed bed becomes large compared with other sections. And, the amount of CO2 hydrate estimated from temperature rise decreases as Reynolds number increases. Friction factor is also estimated. As the result, the difference of the friction factor between both conditions becomes small with increase of Reynolds number in the upstream part of the packed bed. These results suggest that the hydrate formation is not so significant for liquid CO2 injection into the packed bed under the present high Reynolds number conditions. Furthermore, friction factor and water saturation are compared with the relative permeability model. As the result, it is suggested that pressure drop for water-liquid CO2 two-phase flow with the hydrate formation in the packed bed can be estimated by using the relative permeability model within the present experimental conditions. (C) 2013 Elsevier Ltd. All rights reserved.