Main aim of this study is to investigate hydrogen production potential of Advanced Power EXtraction (APEX) fusion reactor cooled with the molten-salt mixtures, as well as its neutronic performance to transmute minor actinides (MAs). In the original APEX reactor concept, fusion power (P-f) is quite high (4000 MW), and the FLiBe molten-salt flows as molten-salt wall. The FLiBe molten-salt is mixed with molten minor actinide tetra fluoride salt (MAF(4)) to transmute minor actinides, and at the same time, to increase the energy multiplication. In addition to this mixture of FLiBe and MAF(4), FLiNaBe, LiF and Eutectic Lithium instead of FLiBe are mixed individually with MAF(4), and are used as the molten-salt coolant. Furthermore, two different compositions of MA nuclides are considered as follows: (i) The MA nuclides discharged from the pressured water reactor (PWR)-MOX spent fuel and (ii) The MA nuclides discharged from the PWR-UO2 spent fuel. The neutronic analyses have been performed for these eight different molten-salt mixture cases and for both one and three-dimensional geometry models by using the XSDRNPM/SCALE4.4a neutron transport code and the MCNP4B code, respectively. In order to produce hydrogen in large-scale, Steam-Methane Reforming (SMR) combined with the Mineral CO2 Sequestration (MCS) is selected. Furthermore, the sulfur iodine (S I) thermochemical water splitting and high-temperature electrolysis (HTE) cycles, which are the most promising water-splitting cycles, are analyzed. The results of calculations bring out that the considered fusion reactor has a good neutronic performance, and it can produce in a considerable amount of the hydrogen production (up to 426 kg/s), as well as the minor actinide transmutation (up to 4.849 t/yr). (C) 2010 Professor T. Nejat Veziroglu. Published by Elsevier Ltd. All rights reserved.