A life cycle analysis of hydrogen is presented involving several processes of H-2 production. The main goal was to adapt the GREET 1.8c model in order to represent the European reality and more specifically the Portuguese energy sector. GEMIS model was used in order to obtain energy consumption and pollutant emissions related to the production of photovoltaic panels and wind towers, since GREET model consider zero emissions in renewable technologies. The integration between these two models generated MACV2H(2) model that was calibrated. The main conclusions from a Well-To-Wheel (WTW) analysis are that wind energy is the best way to produce hydrogen, and its application in Fuel Cell Vehicles (FCV) presents less 85% of greenhouse gases emissions (GHGs) when compared with the gasoline vehicle. In the opposite situation, the FCV with hydrogen from electrolysis using the Portuguese electricity grid presents an increase of 43% on GHGs. Copyright (C) 2012, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.