In order to release resource shortage constraints, hydrogen effective use is of great importance for refineries nowadays. Hydrogen utility consumption in a hydrogen network involving regeneration can be reduced further compared to that of the network involving reuse only. In this article, an iterative method is presented for design of hydrogen networks involving regeneration reuse. The following new insight obtained in water networks is adopted: the hydrogen network involving regeneration can be formed by adding the regenerated stream into the original hydrogen network. This will simplify the design and targeting of the networks with regeneration unit(s). The iterative method proposed can be used to design and target the networks with both fixed regenerated concentration and that with fixed hydrogen recovery ratio. An estimation method is proposed to calculate the regenerated concentration and flow rate for the regeneration unit with fixed hydrogen recovery ratio. A few literature examples are investigated with the proposed method. The results obtained in this work are comparable to that obtained in the literature. It is shown that the method proposed is simple and effective. Copyright (C) 2013, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.