This is the first-time reporting on the photocatalytic production of hydrogen gas (H-2) via water splitting in the presence of swine sewage (SS) as sacrificial agent. H-2 was evolved upon both UV-A and solar light irradiation in presence of platinised titania as the catalyst. The influences of irradiation time, catalyst amount, pH and SS concentration on the reaction yield were investigated. Under the best conditions, up to 50 mu mol of H-2 were produced from aqueous SS (1.7% v/v, COD 82 mg L-1), with good within-laboratory reproducibility (RSD <3%, n = 3). The batch-to-batch reproducibility was verified, too. Despite the complexity of the matrix, the amount of evolved H-2 was about a half of that obtained by use of model sacrificial agents as glucose, sucrose and glycerol, known to be excellent electrondonors. The catalyst, recovered after irradiation, was regenerated by mere washing with acidic water and conserved part of the activity for reusing for at least 3 runs. The proposed procedure is at low environmental impact, does not release carbon dioxide and proceeds also under solar light with reaction yields up to 94% compared to those observed under UV-A radiation. This explorative study demonstrates that a waste such as SS is a rewarding and inexpensive feedstock to produce a high-value chemical as hydrogen gas. The results suggest that further work should be addresses in this direction. Copyright (C) 2014, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.