A Lagrangian simulation for aerosol particle transport and deposition in a chamber is developed. The eddy interaction model (EIM) is adopted to generate the instantaneous turbulent fluctuating velocity field. It is found that a satisfactory result can be obtained only when the near-wall grid is sufficiently fine and the near-wall turbulent kinetic energy is damped effectively according to its component normal to the wall. Seven particle size groups ranging from 0.01 to 10 mu m are studied. A comparison between the current numerical model and a semi-empirical expression indicates that improved deposition fraction results were obtained. The particle deposition and particle fate in the chamber are also presented. (c) 2006 Elsevier Ltd. All rights reserved.