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Journal of Colloid and Interface Science, Vol.374, 1-8, 2012
Hydroxyapatite-armored poly(epsilon-caprolactone) microspheres and hydroxyapatite microcapsules fabricated via a Pickering emulsion route
Hydroxyapatite (HAp) nanoparticle-armored poly(epsilon-caprolactone) (PCL) microspheres were fabricated via a "Pickering-type" emulsion solvent evaporation method in the absence of any molecular surfactants. It was clarified that the interaction between carbonyl/carboxylic acid groups of PCL and the HAp nanoparticles at an oil-water interface played a crucial role in the preparation of the stable Pickering-type emulsions and the HAp nanoparticle-armored microspheres. The HAp nanoparticle-armored PCL microspheres were characterized in terms of size, size distribution, morphology, and chemical compositions using scanning electron microscopy, laser diffraction, energy dispersive X-ray microanalysis, and thermogravimetric analysis. The presence of HAp nanoparticles at the surface of the microspheres was confirmed by scanning electron microscopy and energy dispersive X-ray microanalysis. Pyrolysis of the PCL cores led to the formation of the corresponding HAp hollow microcapsules. (C) 2012 Elsevier Inc. All rights reserved.