The worldwide demands are rising for an energy-efficient and cost-effective approach that can provide advanced nanofibrous membranes with high filtration performance and superior antifouling properties. Here we report a novel synthesized fluorinated polyurethane (FPU) modified nanofibrous membrane optimized to achieve oil and non-oil aerosol particle filtration. By employing the FPU incorporation, the polyacrylonitrile/polyurethane (PAN/PU) composite membranes were endowed with superhydrophobicity with a water contact angle of 154 degrees and superoleophobicity with an oil contact angle of 151 degrees. Morphology, surface wettability, porous structure, and filtration performance could be manipulated by tuning the solution composition as well as the hierarchical structure. Furthermore, the as-prepared membranes can capture, for the first time, a range of different oil aerosol particles in a single-unit operation, with >99.9% filtration efficiency, by using the combined contribution of fiber diameter and surface roughness acting on the objective particles. Exemplified here by the construction of superamphiphobic nanofibrous membrane, numerous applications of this medium includes high efficiency particulate air filters, ultra-low penetration air filters, and respiratory protection equipment. (C) 2014 Elsevier Inc. All rights reserved.