Assessment of seasonal changes in surface water quality is an important aspect for evaluating temporal variation of water due to natural or anthropogenic inputs of point and non-point sources. The objective of this paper was to investigate the influence of seasonal temperature fluctuations and precipitations on the levels of BTEX in natural waters. Principal component analysis (PCA) was used to evaluate the seasonal correlations of BTEX levels in water and to extract the parameters that are most important in assessing seasonal variations of water quality. This study was carried out as a part of VOCs monitoring program in natural water samples from Mediterranean coast. To carry out this project, a multiresidue analytical method was used. The method was based on headspace solid-phase microextraction (HS-SPME) followed by gas chromatography coupled to flame ionization detector (FID). The limits of detection LODs found for the tested analyte tested were in the 0.001-1 mu g/L range. These values were adequate for the analysis of these compounds in water samples according to the regulated values. Water samples from different points of the Mediterranean coast were analyzed during a period of three years, and were taken four times per year. Most of the compounds were below the limit established by the legislation. The results obtained by a chemometric study indicated that temperature and precipitations can be related on the BTEX levels found in water. A regression model between temperature or precipitations and BTEX concentration was obtained, thus these models can be used as predictive model for detection any non-normal concentration level. (C) 2013 Elsevier B.V. All rights reserved.