The behavior of multiple runaway reactions is more complex and difficult to predict compared with that of a (more conventional) single runaway reaction. A model to predict the multiple runaway reactions associated with MEK oxidation is proposed here, and the prediction curves are compared with experimental data. Our study includes a systematic procedure to determine the thermodynamic and kinetic parameters of individual reactions and a kinetic model to describe multiple runaway-reaction behaviors. The results revealed that this model for the multiple runaway-reaction system can be used to predict both the time-temperature profile precisely, and the temperature-self heat rate curve approximately.