Computational Fluid Dynamics (CFD) approach has been successfully applied to simulate the small-scale instantaneous flashing release experiment by Pettitt. A model for dispersion of the release event is provided based on relevant theories and existing experimental data. An application of the CFD method to the dispersion simulation is illustrated. Furthermore, a new methodology based on discrete phase model for setting computational initial conditions is provided. An initial expansion and subsequent turbulence dispersion can be characteristically identified from both volume and temperature variation of the cloud obtained by the simulation. The possible mechanism for these phenomena has also been discussed and analyzed. The study deepens the understanding of the physical process of this event and provides one more reliable tool for relevant safety systems. (c) 2011 Elsevier Ltd. All rights reserved.