The transportation of hazardous materials by road is an utmost necessity of the world for the societal benefits, but at the same time the activity is inherently dangerous. Incidents involving hazardous material (hazmat) cargo particularly the class-2 materials can lead to severe consequences in terms of fatalities, injuries, evacuation, property damage and environmental degradation. The rationale behind considering class-2 hazmats is that they pose the greatest danger to the people and property along the transport route because of their storage condition on the transport vessel. They are stored either in pressurized vessels or in cryogenic containers. Any external impact due to collision may cause catastrophic failure of transport vessels, known as BLEVE (Boiling Liquid Expanding Vapour Explosion) with devastating consequences. Further, any continuous release from containment may cause what is known as 'Unconfined Vapour Cloud Explosion' (UVCE). Historically frequency of BLEVE occurrence is of the order of 1 x 10(-6) per year or less, but other release scenarios e.g. a large vapour or liquid leaks are more probable and could also have devastating effects on the surrounding population. As such, the paper discussed various event scenarios and the consequences taking examples of a class-2.1 material (1,3 butadiene) and another class-2.3 (ammonia) hazmat. Comparative analysis suggests that per ton basis a rupture of ammonia tanker gives rise to larger impact areas and poses larger lethality risks compared to 1,3 butadiene as far as toxic effects are concerned. Besides, from fireball fatality on similar basis propylene causes higher consequence distance than LPG followed by ethylene oxide and 1,3 butadiene. The impact zone study results may be utilized as inputs for identifying the potential vulnerable area on a GIS enabled map, along a designated State highway route passing through an important industrial corridor in western India. (C) 2011 Published by Elsevier Ltd.