In this paper we show the integration of techniques for early fault detection and diagnosis of operational faults in industrial processes, and we show an application example in a Fluid Catalytic Cracking refinery process. The early fault detection and diagnosis allow the operators in an industrial process to take the best actions during the real state of the process, avoiding incipient faults to scale to critical situations where there is risk of human lives and economical lost. (C) 2013 Elsevier Ltd. All rights reserved.