Thin film composite (TFC) membranes are critical components for reverse osmosis (RO) and nanofiltration (NF) processes. Similar to other liquid-based filtration membranes, TFC membranes are susceptible to concentration polarization and fouling/scaling. Recently, surface topography modification has been shown as a potential approach for fouling mitigation. However, for TFC membranes, tailoring the surface topography remains a challenge. Here, we demonstrate for the first time, successful fabrication of a patterned TFC membrane. A two-step fabrication process was carried out by (1) nanoimprinting a polyethersullone (PES) support, and (2) forming a thin dense film atop the FES support via interfacial polymerization (IF) with trimesoyl chloride and 1,3-phenylenediamine solutions. Chemical, topographic, and permeation characterization was performed on the imprinted lP membranes, and their permselectivity was compared with that of a flat (non-imprinted) TFC membrane prepared using he same lP procedure. (C) 2013 Elsevier B.V. All rights reserved.