A series of diarylpyrymidin-2(1H)-one (DAPM) belongs to one of the important class of therapeutic and pharmacological active hetrocycles, were synthesized through the multicomponent reactions (MCRs) of aldehydes, ketone and urea, followed by the heterogeneous catalysis. The synthetic utility of this method is well demonstrated by avoiding expensive reagent TMSCI, using large pore zeolites (H-MOR, HY and H-BEA) as potential solid acid catalyst. Key role of textural properties such as surface acidity, hydrophobicity and porosity on catalytic activity of the zeolites on the synthesis of DAPMs has also been described. (C) 2011 Elsevier B.V. All rights reserved.