A highly well-organized heterogeneous protocol is developed for the simple synthesis of bis(indolyl)methanes by the effective mediation of an inorganic-organic hybrid material prepared by the chemically anchoring of H5PW10V2O40 onto mesoporous silica (SBA-15). Standard characterization data such as XRD, SEM, and FT-IR for the obtained catalyst verified that the ordered hexagonal mesoporous structure of SBA-15 and the Keggin structure of tungstovanadophosphoricacid on pyridine modified SBA-15 surface are preserved. Reusability experiments demonstrated that the active sites on the pyridine modified SBA-15 mesoporous silica retained their structure after several cycles. (c) 2012 Elsevier B.V. All rights reserved.