Material degradation is a major issue for solid oxide fuel cells servicing under severe high temperature environments. This work studies the interaction between (La1-xSrx)(n)Co1-yFeyO3-delta (LSCF) cathode and AISI 441 alloy interconnect at 800 degrees C by investigating the interfacial reaction and degradation through an AISI 441 interconnect/LSCF electrode/yttria-stabilized zirconia (YSZ) electrolyte tri-layer structure. LSCFs with different stoichiometries are created in order to understand cathode composition effect on solid oxide fuel cell performance. The porous microstructures of the electrodes experience significant evolution after the thermal treatment under current load. Energy dispersive X-ray spectroscopy and X-ray photoelectron spectroscopy analyses reveal the significance of elemental distributions on the performance of the cathodes. Cr, La, and Co distributions vary with stoichiometry. Ohmic resistance and polarization resistance of the cathodes are analyzed by deconvoluting the electrochemical impedance spectroscopy (EIS) results. Based on the elemental distribution, the microstructure evolution of the LSCF electrodes, and the EIS analysis, the interaction mechanisms between the LSCF electrodes and the AISI 441 alloy are proposed. Overall, the A-site deficient stoichiometry is preferred. (C) 2013 Elsevier B.V. All rights reserved.