The ammoximation of cyclohexanone to cyclohexanone oxime with H2O2 and NH3, in liquid phase, over gamma-Al2O3 supported titanium silicates, is reported. The effects of temperature, reactant concentrations and support to catalyst ratio on the efficiency of the process are examined. A maximum yield of 94 . 48% with selectivity 98 . 49% for oxime could be achieved over 50 wt% gamma-Al2O3 supported titanium silicates, at a cyclohexanone : NH3 : H2O2 molar ratio of 1 : 1 . 5 : 1, and at a temperature of 313 K. Studies suggest that in the case of a supported catalyst, the catalyst : ketone ratio is about eight times less than that needed for an unsupported catalyst. A batchwise addition of cyclohexanone and ammonia and a dropwise addition of H2O2 produced the best results. A tentative mechanism for the production of oxime and by-products is suggested.