This paper proposes a control strategy for an automotive selective catalytic reduction (SCR) system using a NO sensor in a feedback loop. As is representative of real world applications, the employed NOx sensor is cross-sensitive to NH3, which induces several complexities. In particular the ambiguity of the measurements could be detrimental to the closed loop response, as it generates multiple equilibrium points (artefacts), besides the point of practical interest. A study of the closed-loop dynamics is performed in the vicinity of each point, which shows that the closed loop system naturally converges to the point of interest not to the artefacts. Experimental results obtained after a detailed calibration method illustrate the relevance and performance of the proposed approach. (C) 2013 Elsevier Ltd. All rights reserved.