Acetophenone and its derivatives undergo various transformations in binary supercritical solvent isopropanol/CO2 in a flow reactor in the presence of granulated Al2O3. Depending on the reaction temperature, respective secondary alcohols, or isopropyl ethers, or substituted styrenes are formed at contact times of similar to 4 min. Selectivity for the reaction products attains 96% at high conversion of initial compounds. It was shown that the nature of a substituent in ketone aromatic ring exerts primary effect both on the conversion of initial compounds and on stability of intermediates under reaction conditions, and thus affects the end product distribution. (C) 2012 Elsevier B.V. All rights reserved.