In the present study, solubility of ketoprofen in the supercritical carbon dioxide was measured experimentally using gravimetric method. In this direction the temperature and pressure was ranged between 308.15-338.15K and 160-400 bar, respectively. The obtained solubilites revealed that the ketoprofen solubility was in the range of 2.21 x 10(-5) to 7.12 x 10(-4) mole fraction according to the different temperatures and pressures. Measured solubilites demonstrated that pressure and temperature have a direct effect on the solubility enhancement. Finally, the least square method and curve fitting approaches were utilized to find the fitting parameters of four semi-empirical density based correlations including Mendez-Santiago-Teja, Bartle, Chrastile and Kumar and Johnston methods. The results revealed that Bartle et al. method was able to correlate the ketoprofen solubility with a minimum average absolute relative deviation (AARD %) of 5.95%. (C) 2012 Elsevier B.V. All rights reserved.