The solubilities of desoxycorticosterone acetate (DA) and clobetasole propionate (CP) in supercritical carbon dioxide (SC-CO2) were measured at temperature ranging from (308 to 348) K and pressures from (12.2 to 35.5) MPa using a static method. The mole fraction solubilities ranged from 10-7 to 13.93 x 10(-5). The crossover region was observed for DA and CP at 243 and 25.3 MPa, respectively. Solubility data were correlated using four semi-empirical density-based models (Chrastil, Bartle, Kumar, Johnston (K-J) and Mendez-Santiago and Teja (M-T) models). The average absolute relative deviations (AARD%) ranged from 9.3 to 13.6; 8.9 to 11.9; 6.5 to 10.3 and from 10.4 to 13.4 for Chrastil, Bartle, K-J and M-T models, respectively. A comparison among the four models revealed that the K-J model gave much better correlation of the solubilities in comparison with other models. Using the correlation results, the heat of drug-CO2 solvation and that of drug vaporization was separately approximated in the range of -24.2 to -24.5 and 63.8 to 64.8 kJ mol(-1). The correlation results showed good agreement with the experimental data. (C) 2013 Elsevier B.V. All rights reserved.