This paper addresses the development of an internet-based interactive globoidal indexing design system and methods. We adopt a client/server architecture. The developed system uses Java as the programming language, Java3D as the graphics API and XML as the information exchange file format so as to provide the flexibility of interoperability on a variety of operating platforms. The system embeds the cam shape data of the B-spline model into the XML file. This enhances the profile representation of a cam, yet keeps the representation compact. The interactive cam optimization design methodology is integrated. The prototype system indicates that the system can serve as the effective tool for designing globoidal indexing cam mechanism with the better properties of interaction and expansion.