The layered manganese oxides LaSr(2)Mn(2-x)TxO(7) (T = Fe, Cr and Ni) has been prepared. The effect of substitution of transition metal ions for Mn on magnetic and magtoresistance properties has been studied. The compound has a tetragonal symmetry and the lattice parameters a decreases with increasing the doped content but the parameter c increases with x. It indicates that the MnO6 octahedron increase the distortion with x content. With the x increase, their ferromagnetic property was depressed. The Neel temperature T-N was depressed gradually from 138K to 89K, 95K and 85K at x = 0.3 for T = Fe, Ni and Cr respectively. Their magnetoresistance MR is gradually enhanced for all doped system. It suggests that the introduce of disorder in B-site have an important effect on the magnetic exchange and magnetoresistance because of the weaken of the double-exchange (DE) interaction.