Features of catalytic cracking of mixtures of a hydrotreated vacuum distillate and oxygenated compounds derived in biofuel production (acetone, glycerol, and methanol) over a microspherical zeolite-containing catalyst have been studied. It has been found that these oxygenated compounds undergo complete conversion under catalytic cracking conditions. The dependence of the process parameters on the reaction temperature and the concentration of oxygenated additives has been examined. The possible chemistry and mechanism of conversion of the oxygenated compounds under catalytic cracking have been discussed.