Simultaneous control of multi-pollutants emission from coal-fired flue gas is essential for environmental quality. Non-thermal plasma (NTP) technologies have made numerous successful applications of combined removal for sulfur dioxide (SO2), nitrous oxide, particulate matter and mercury. Nitric oxide, elemental mercury can be oxidized in the gas phase, while fine particle gets agglomeration in the same NTP device. SO2 gets absorbed after heterogeneous oxidation by discharge. All the gaseous pollutants and aerosols generated will be further oxidized and captured in wet NTP device. Applications of NTP and typical configurations are also summarized.