CuO as a semiconductor as incorporated onto an Iranian natural Clinoptilolite zeolite, was prepared by calcination of Cu(II)-ion exchanged Clinoptilolite. The obtained composite was used as a photocatalyst to degrade a p-aminophenol aqueous solution. All raw and modified samples were characterized using XRD, FT-IR, BET and SEM methods. The degradation and mineralization extents were performed by UV-vis spectrophotometry, COD and HPLC The optimum values of the experimental parameters which affect the degradation efficiency were obtained as: 2.0 gL(-1) of the photocatalyst, 20 ppm of p-aminophenol and pH 6.0. Hydrogen peroxide and potassium bromate considerably increased the rate of degradation. Zeolite bed had considerable role in the photodegradation efficiency, so the proposed catalyst significantly increased the efficiency with respect to CuO and especially Clinoptilolite alone. (c) 2012 Elsevier B.V. All rights reserved.