Chrysanthemum zawadskii extract activates peroxisome proliferator-activated receptor-α and has an anti-inflammatory activity : Potential interest for the skin barrier function

Bora Kim; Hyun-Soo Kim

Korean Journal of Chemical Engineering, Vol.31, No.10, 1831-1838, October, 2014

DOI10.1007/s11814-014-0109-0 Export Citation

Chrysanthemum zawadskii extract activates peroxisome proliferator-activated receptor-α and has an anti-inflammatory activity : Potential interest for the skin barrier function

Bora Kim, and Hyun-Soo Kim^{1, †}

Skin and Bio Research, Ellead Co., Ltd., Gyeonggi 463-824, Korea
¹Department of Food Science and Industry, Jungwon University, Chungbuk 367-805, Korea

E-mail:

Chrysanthemum zawadskii extract (CZE) was investigated to determine its effects on the transactivation activity of peroxisome proliferator-activated receptors (PPAR)-responsive element (PPRE) and activity of anti-inflammatory for improvement of skin barrier function. The treatment with CZE resulted in a significant increase in the transactivation activity of PPRE such as PPAR-α and suppression in the TNF-α-, IL-6-induced NF-κB luciferase activity and NO production. In addition, CZE promotes the expression of protein related to cornified envelope (CE) formation such as involucrin. Therefore, these results indicate that CZE can restore skin barrier homeostasis and is suggested to be an appropriate skin therapeutic agent.

Keywords:Peroxisome Proliferators Activated Receptors;Anti-inflammation;Chrysanthemum zawadskii Extract

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[2] Holleran WM, Takagi Y, Menon GK, Jackson SM, Lee JM, Feingold KR, Elias PM, J. Lipid Res., 35, 905 (1994)

[3] Downing DT, J. Lipid Res., 33, 301 (1992)

[4] Schoonjans K, Staels B, Auwerx J, J. Lipid Res., 37, 907 (1996)

[5] Kersten S, Desvergne B, Wahli W, Nature, 405, 421 (2000)

[6] Kuenzli S, Saurat JH, Br. J. Dermatol., 149(2), 229 (2003)

[7] Dubrac S, Schmuth M, Dermatoendocrinol., 3, 23 (2011)

[8] Komuves LG, Hanley K, Lefebvre AM, Man MQ, Ng DC, Bikle DD, Williams ML, Elias PM, Auwerx J, Feingold KR, J. Invest. Dermatol., 115(3), 353 (2000)

[9] Hanley K, Jiang Y, Crumrine D, Bass NM, Appel R, Elias PM, Williams ML, Feingold KR, J. Clin. Invest., 100(3), 705 (1997)

[10] Sher T, Yi HF, McBride OW, Gonzalez FJ, Biochemistry, 32(21), 5598 (1993)

[11] Asavapanumas N, Kittayaruksakul S, Meetam P, Muanprasat C, Chatsudthipong V, Soodvilai S, Drug Metab. Pharmacokinet., 27(5), 513 (2012)

[12] Wang S, Hannafon BN, Zhou J, Ding WQ, Cell. Physiol. Biochem., 32(5), 1255 (2013)

[13] Reichenbach G, Starzinski-Powitz A, Sloane BF, Doll M, Kippenberger S, Bernd A, Kaufmann R, Meissner M, Angiogenesis., 16(1), 223 (2013)

[14] Clevers H, Cell., 118(6), 671 (2004)

[15] Zedler S, Faist E, Curr. Opin. Crit. Care., 12(6), 595 (2006)

[16] Mariathasan S, Monack DM, Nat. Rev. Immunol., 7, 31 (2007)

[17] Dokka S, Shi X, Leonard S, Wang L, Castranova V, Rojanasakul Y, Am. J. Physiol. Lung Cell Mol. Physiol., 280, 1196 (2001)

[18] Kang JW, Choi SC, Cho MC, Kim HJ, Kim JH, Lim JS, Kim SH, Han JY, Yoon DY, Immunology, 128, 532 (2009)

[19] Makarov SS, Mol. Med. Today, 6(11), 441 (2000)

[20] Yamamoto Y, Gaynor RB, Curr. Mol. Med., 1(3), 287 (2001)

[21] Kwon HS, Ha TJ, Hwang SW, Jin YM, Nam SH, Park KH, Yang MS, J. Life Sci., 16, 746 (2006)

[22] Herzi N, Bouajila J, Camy S, Cazaux S, Romdhane M, Condoret JS, J. Food Sci., 141(4), 3537 (2013)

[23] Seo JY, Lim SS, Park J, Lim JS, Kim HJ, Kang HJ, Park JH, Kim JS, Nutr. Res. Pract., 4(2), 93 (2010)

[24] Suh KS, Rhee SY, Jung WW, Kim NJ, Jang YP, Kim HJ, Kim MK, Choi YK, Kim YS, Int. J. Mol. Med., 32(1), 241 (2013)

[25] Zheng J, Chen Y, Yao F, Chen W, Shi G, Mar Drugs., 10, 2634 (2012)

[26] Sharma KV, Sisodia R, J. Radiol. Prot., 29, 429 (2009)

[27] Kim SH, Nam GW, Lee HK, Moon SJ, Chang IS, Arch. Dermatol. Res., 298(6), 273 (2006)

[28] Banskota AH, Tezuka Y, Nguyen NY, Awale T, Vobukawa T, Kadota S, Planta. Med., 69(6), 500 (2003)

[29] Eads D, Hansen RL, Oyegunwa AO, Cecil CE, Culver CA, Scholle F, Petty ITD, Laster SM, J. Inflamm., 6, 1 (2009)

[30] Uesawa Y, Mohri K, J. Pharm. Soc. Jpn., 125, 875 (2005)

[31] Wakita H, Takigawa M, J. Biol. Chem., 274, 37285 (1999)

[32] Balasubramanian S, Sturniolo MT, Dubyak GR, Eckert RL, Carcinogenesis., 26(6), 1100 (2005)