Preparation and Core-polymerization of MePEG/PDLLA Block Copolymer Micelle (I)

Ji-Heung Kim; Yokio Nagasaki; Kazunori Kataoka

Journal of Industrial and Engineering Chemistry, Vol.4, No.3, 244-250, September, 1998

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Preparation and Core-polymerization of MePEG/PDLLA Block Copolymer Micelle (I)

Ji-Heung Kim^†, Yokio Nagasaki¹, and Kazunori Kataoka¹

Department of Chemical Engineering, Sungkyunkwan University, Kyonggi 440-746, Korea
¹Department of Materials Science and Technology, Science University of Tokyo, Chiba 278, Japan

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MePEG/PLA block copolymer with polymerizable methacrylate end was prepared by anionic ring opening polymerization and end-capping using methacrylic anhydride. A stable core-shell type micelle with average diameter of ca. 30 nm was obtained by dialysis method, and the resulting aqueous micelle solution was core-polymerized chemically and photochemically to produce more stable nanoparticles, which was evidenced by spectroscopy and light scattering technique.

Keywords:PEG/PLA;block copolymer;micelle;core-polymerization

[References]

Bader H, Ringsdorf H, Schmidt B, Angew. Makromol. Chem., 123-124, 457 (1984)
Gao Z, Eisenberg A, Macromolecules, 26, 7353 (1993)
Kwon GS, Naito M, Yokoyama M, Okano T, Sakurai Y, Kataoka K, Langmuir, 9, 945 (1993)
Xu R, Winnik M, Riess G, Chu B, Croucher MD, Macromolecules, 25, 644 (1992)
Yokoyama M, Crit. Rev. Ther. Drug Carrier Systems, 9, 213 (1992)
Wrana J, Pawson T, Nature, 388(6637), 28 (1997)
Zareie HM, Kaitian X, Piskin E, Colloids Surf. A: Physicochem. Eng. Asp., 112, 19 (1996)
Tanodekaew S, Pannu R, Heatley F, Attwood D, Booth C, Macromol. Chem. Phys., 198, 927 (1997)
Ramasmamy M, Zhang X, Burt HM, Wasan KM, J. Pharm. Sci., 86(4), 460 (1997)
Peracchia MT, Gref R, Minamitake Y, Domb A, Lotan N, Langer R, J. Control. Release, 46, 223 (1997)
Hagan SA, Coombes AG, Garnett MC, Dunn SE, Davis MC, Illum L, Davis SS, Harding SE, Purkiss S, Gellert PR, Langmuir, 12(9), 2153 (1996)
Bazile D, Prudhomme C, Bassoullet MT, Marlard M, Spenlehauer G, Veillard M, J. Pharm. Sci., 84(4), 493 (1995)
Piskin E, Kaitian X, Denkbas EB, Kucukyavuz Z, J. Biomater. Sci.-Polym. Ed., 7(4), 359 (1995)
Zhang X, Jackson JK, Burt HM, Int. J. Pharm., 132, 195 (1996)
Yokoyama M, Okano T, Sakurai Y, Ekimoto H, Shibazaki C, Kataoka K, Cancer Res., 51, 3229 (1991)
Tuzar Z, Webber SE, Prochazka K, Ramireddy C, Munk P, Polym. Prepr. ACS Div. Polym. Chem., 32, 525 (1991)
Dong DC, Winnik MA, Can. J. Chem., 62, 2560 (1984)
Zhao CL, Winnik MA, Riess G, Croucher MD, Langmuir, 6, 514 (1990)
Cao T, Munk P, Ramireddy C, Tuzar Z, Webber SE, Macromolecules, 24, 6300 (1991)
Kwon GS, Naito M, Kataoka K, Yokoyama M, Sakurai Y, Okano T, Colloids Surf. B: Biointerfaces, 2, 429 (1994)
Dowling KC, Thomas JK, Macromolecules, 23, 1059 (1990)

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[2] Gao Z, Eisenberg A, Macromolecules, 26, 7353 (1993)

[3] Kwon GS, Naito M, Yokoyama M, Okano T, Sakurai Y, Kataoka K, Langmuir, 9, 945 (1993)

[4] Xu R, Winnik M, Riess G, Chu B, Croucher MD, Macromolecules, 25, 644 (1992)

[5] Yokoyama M, Crit. Rev. Ther. Drug Carrier Systems, 9, 213 (1992)

[6] Wrana J, Pawson T, Nature, 388(6637), 28 (1997)

[7] Zareie HM, Kaitian X, Piskin E, Colloids Surf. A: Physicochem. Eng. Asp., 112, 19 (1996)

[8] Tanodekaew S, Pannu R, Heatley F, Attwood D, Booth C, Macromol. Chem. Phys., 198, 927 (1997)

[9] Ramasmamy M, Zhang X, Burt HM, Wasan KM, J. Pharm. Sci., 86(4), 460 (1997)

[10] Peracchia MT, Gref R, Minamitake Y, Domb A, Lotan N, Langer R, J. Control. Release, 46, 223 (1997)

[11] Hagan SA, Coombes AG, Garnett MC, Dunn SE, Davis MC, Illum L, Davis SS, Harding SE, Purkiss S, Gellert PR, Langmuir, 12(9), 2153 (1996)

[12] Bazile D, Prudhomme C, Bassoullet MT, Marlard M, Spenlehauer G, Veillard M, J. Pharm. Sci., 84(4), 493 (1995)

[13] Piskin E, Kaitian X, Denkbas EB, Kucukyavuz Z, J. Biomater. Sci.-Polym. Ed., 7(4), 359 (1995)

[14] Zhang X, Jackson JK, Burt HM, Int. J. Pharm., 132, 195 (1996)

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[16] Tuzar Z, Webber SE, Prochazka K, Ramireddy C, Munk P, Polym. Prepr. ACS Div. Polym. Chem., 32, 525 (1991)

[17] Dong DC, Winnik MA, Can. J. Chem., 62, 2560 (1984)

[18] Zhao CL, Winnik MA, Riess G, Croucher MD, Langmuir, 6, 514 (1990)

[19] Cao T, Munk P, Ramireddy C, Tuzar Z, Webber SE, Macromolecules, 24, 6300 (1991)

[20] Kwon GS, Naito M, Kataoka K, Yokoyama M, Sakurai Y, Okano T, Colloids Surf. B: Biointerfaces, 2, 429 (1994)

[21] Dowling KC, Thomas JK, Macromolecules, 23, 1059 (1990)